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jem Home » 1990 Archive » 1 April » 171 (4): 1369
Article

Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanism.

G E Rice, J M Munro, M P Bevilacqua
G E Rice
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J M Munro
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M P Bevilacqua
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DOI: 10.1084/jem.171.4.1369 | Published April 1, 1990
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Abstract

Inducible cell adhesion molecule 110 (INCAM-110) is a 110-kD glycoprotein expressed on cytokine-activated human vascular endothelial cells. mAb blocking studies indicate that INCAM-110 and intercellular adhesion molecule 1 (ICAM-1) independently support the adhesion of lymphocytes to activated human umbilical vein endothelial cell monolayers. Anti-CD11a/CD18 antibodies with anti-INCAM-110 mAb E1/6 produce greater inhibition of lymphocyte adhesion than either reagent alone, suggesting that INCAM-110 and LFA-1 are not an obligate receptor-ligand pair. Blood monocytes, but not polymorphonuclear leukocytes, also appear to bind endothelial INCAM-110. Endothelial expression of INCAM-110 is upregulated at sites of inflammation, suggesting a role in the recruitment of mononuclear leukocytes.

© 1990 Rockefeller University Press
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Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanism.
G E Rice, J M Munro, M P Bevilacqua
Journal of Experimental Medicine Apr 1990, 171 (4) 1369-1374; DOI: 10.1084/jem.171.4.1369

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The Journal of Experimental Medicine: 215 (4)

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April 2, 2018
Volume 215, No. 4

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