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jem Home » 1989 Archive » 1 August » 170 (2): 355
Article

T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats.

H Offner, G A Hashim, B Celnik, A Galang, X B Li, F R Burns, N Shen, E Heber-Katz, A A Vandenbark
H Offner
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G A Hashim
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B Celnik
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A Galang
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X B Li
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F R Burns
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N Shen
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E Heber-Katz
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A A Vandenbark
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DOI: 10.1084/jem.170.2.355 | Published August 1, 1989
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Abstract

The major encephalitogenic epitope for Lewis rats is the 72-89 sequence of guinea pig basic protein (GP-BP) or rat basic protein (Rt-BP). T cells responsive to this epitope are I-A restricted and preferentially express the V alpha 2:V beta 8 gene combination in their TCR. In this work, we describe for the first time the delayed appearance of T cells specific for additional discrete determinant of BP, the nonencephalitogenic 55-68 sequence of GP-BP restricted by I-A, and the encephalitogenic 87-99 sequence of Rt-BP restricted by I-E. The TCR V alpha 2:V beta 8 gene combination was expressed by both encephalitogenic GP-BP S72-89 and Rt-BP S87-99 T cell specificities but not by GP-BP 44-68-specific T cells. This is the first demonstration of I-E-restricted encephalitogenic T cells in Lewis rats and supports the conclusion that the I-E class II locus is involved in autoimmune diseases.

© 1989 Rockefeller University Press
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T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats.
H Offner, G A Hashim, B Celnik, A Galang, X B Li, F R Burns, N Shen, E Heber-Katz, A A Vandenbark
Journal of Experimental Medicine Aug 1989, 170 (2) 355-367; DOI: 10.1084/jem.170.2.355

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The Journal of Experimental Medicine: 215 (4)

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April 2, 2018
Volume 215, No. 4

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