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jem Home » 1987 Archive » 1 February » 165 (2): 531
Article

Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.

C T Lutz, T L Bartholow, N S Greenspan, R J Fulton, W J Monafo, R M Perlmutter, H V Huang, J M Davie
C T Lutz
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T L Bartholow
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N S Greenspan
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R J Fulton
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W J Monafo
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R M Perlmutter
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H V Huang
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J M Davie
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DOI: 10.1084/jem.165.2.531 | Published February 1, 1987
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Abstract

Monoclonal antibodies (mAb) to streptococcal group A carbohydrate (GAC) are encoded by a minimum of two VH, four JH, four V kappa, three J kappa, one V lambda, and one J lambda gene segments. The IdX, IdI-1, and Id5 idiotypic determinants are expressed by anti-GAC mAb and are found on free kappa chains. Each pattern of these determinants is encoded by a distinct V kappa gene segment, apparently without the requirement for a particular J kappa, VH, or JH gene segment, or somatic mutation. In contrast, the binding site-associated idiotypic determinant IdI-3a does not correlate with any single V or J gene segment.

© 1987 Rockefeller University Press
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Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.
C T Lutz, T L Bartholow, N S Greenspan, R J Fulton, W J Monafo, R M Perlmutter, H V Huang, J M Davie
Journal of Experimental Medicine Feb 1987, 165 (2) 531-545; DOI: 10.1084/jem.165.2.531

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The Journal of Experimental Medicine: 215 (4)

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April 2, 2018
Volume 215, No. 4

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