Skip to main content

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subject Collections
    • Meeting Collections
  • Reviews & Opinions
    • Editorials
    • Insights
    • Perspectives
    • Reviews
  • Alerts
  • About
    • History
    • Editors & Staff
    • Policies & Permissions
    • Advertise
    • Contact Us
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Publication Fees
    • Author Services
  • Subscriptions
  • Rockefeller University Press
  • JCB
  • JEM
  • JGP
  • LSA

User menu

  • Log in

Search

  • Advanced search
JEM
  • Rockefeller University Press
  • JCB
  • JEM
  • JGP
  • LSA
  • Log in
JEM

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subject Collections
    • Meeting Collections
  • Reviews & Opinions
    • Editorials
    • Insights
    • Perspectives
    • Reviews
  • Alerts
  • About
    • History
    • Editors & Staff
    • Policies & Permissions
    • Advertise
    • Contact Us
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Publication Fees
    • Author Services
  • Subscriptions

You are here

jem Home » 1984 Archive » 1 April » 159 (4): 1070
Article

Involvement of the K and I regions of the H-2 complex in resistance to hemopoietic allografts.

G Drizlikh, J Schmidt-Sole, B Yankelevich
G Drizlikh
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J Schmidt-Sole
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B Yankelevich
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1084/jem.159.4.1070 | Published April 1, 1984
  • Article
  • Info
  • Metrics
  • Preview PDF
Loading

Abstract

Irradiated (H-2b X H-2k)F1 and (H-2b X H-2d)F1 recipients strongly resist the growth of H-2b parental bone marrow cells and do not resist marrow grafts from non-H-2b parents such as C3H and BALB/c. This phenomenon of hybrid resistance has been shown to be under genetic control of the H-2D-linked loci and was interpreted by Cudkowicz (9) as due to the existence of H-2D-linked recessive hemopoietic histocompatibility genes. To check whether the H-2D-linked loci are solely responsible for the fate of bone marrow allografts, we measured the strength of resistance of irradiated (B6 X C3H)F1 and (B6 X BALB/c)F1 recipients toward bone marrow grafts from a set of H-2 recombinant and F1 hybrid donors carrying either the H-2b, H-2d, and H-2k alleles. We found that growth of all H-2b grafts was resisted, although to different degrees. Resistance was minimal when donors shared with the input strain of a corresponding F1 hybrid the H-2K and H-2I regions, or when both F1 donors and F1 recipients formed identical unique hybrid Ia molecules. In addition, H-2b grafts were resisted by congenic, H-2D-identical, H-2K-and H-2I-incompatible recipients. The fate of grafts from H-2Dd donors seemed to depend on the incompatibility of the combinatorial determinant Ia.22. If both donor and recipient expressed such a determinant (either in the cis or in the transposition), or if neither could form such a determinant, grafts were not resisted. The H-2Dk allele is not the main or only factor that confers on the C3H parental bone marrow cells the ability to grow unresisted in (B6 X C3H)F1 recipients. Grafts from congenic C3H.OH donors, carrying the same H-2Dk alleles and differing in the left part of the H-2 complex, were resisted by the F1 recipients. We conclude that both class I (K and D) and class II (I-A and I-E) major histocompatibility complex genes, rather than hypothetical hemopoietic histocompatibility genes control hemopoietic resistance. To reconcile codominant inheritance of classic H-2 antigens with the apparent recessive inheritance of hybrid resistance, we assume that there exist parental determinants that are not formed in some F1 hybrids due to preferential association of either Ia alpha chains with allogeneic beta chains or of class I antigens with allogeneic or hybrid class II restriction elements.

© 1984 Rockefeller University Press
Previous articleNext article
Back to top
Download PDF
Citation Tools
Involvement of the K and I regions of the H-2 complex in resistance to hemopoietic allografts.
G Drizlikh, J Schmidt-Sole, B Yankelevich
Journal of Experimental Medicine Apr 1984, 159 (4) 1070-1082; DOI: 10.1084/jem.159.4.1070

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Alerts
Sign In to Email Alerts with your Email Address

Email logo Twitter logo Facebook logo Mendeley logo Reddit logo CiteULike logo LinkedIn logo
The Journal of Experimental Medicine: 215 (4)

Current Issue

April 2, 2018
Volume 215, No. 4

  • Table of Contents
  • All Issues

Jump To

  • Article
  • Info
  • Metrics
  • Preview PDF
 

ARTICLES

  • Current Issue
  • Newest Articles
  • Archive
  • Alerts
  • RSS feeds

FOR AUTHORS

  • Submit a Manuscript
  • Instructions for Authors

ABOUT

  • About JEM
  • Editors & Staff
  • Policies & Permissions
  • Advertise
  • Contact Us
  • Feedback
  • Newsroom

CONNECT WITH JEM

  • Email
  • Facebook
  • Twitter
  • RSS
  • Instagram

Online ISSN: 1540-9538
Print ISSN: 0022-1007

Copyright © 2018 JEM by Rockefeller University Press