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jem Home » 1983 Archive » 1 June » 157 (6): 2172
Article

In vitro generation of cytotoxic cells specific for human minor histocompatibility antigens by lymphocytes from a normal donor potentially primed during pregnancy.

W A Tekolf, S Shaw
W A Tekolf
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S Shaw
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DOI: 10.1084/jem.157.6.2172 | Published June 1, 1983
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Abstract

A normal female donor (H9) is described, whose cells generate strong cytotoxicity against a human minor histocompatibility antigen in vitro. These cytotoxic T lymphocytes are generated after secondary restimulation with cells from an HLA-A, -B, -C, and -DR-matched donor and are HLA restricted (HLA-B7). No other donor could be identified whose cells responded to this antigen. The two children of donor H9 are virtually HLA identical to her and one of the children expresses the relevant minor histocompatibility antigen. These data suggest that priming in vivo during pregnancy has facilitated cytotoxic T cell response to human minor histocompatibility antigens in vitro.

© 1983 Rockefeller University Press
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In vitro generation of cytotoxic cells specific for human minor histocompatibility antigens by lymphocytes from a normal donor potentially primed during pregnancy.
W A Tekolf, S Shaw
Journal of Experimental Medicine Jun 1983, 157 (6) 2172-2177; DOI: 10.1084/jem.157.6.2172

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The Journal of Experimental Medicine: 215 (4)

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April 2, 2018
Volume 215, No. 4

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