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jem Home » 1977 Archive » 1 December » 146 (6): 1640
Article

B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production.

M K Hoffmann, C Galanos, S Koenig, H F Oettgen
M K Hoffmann
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C Galanos
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S Koenig
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H F Oettgen
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DOI: 10.1084/jem.146.6.1640 | Published December 1, 1977
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Abstract

The role played by macrophages in two effects of lipopolysaccharide (LPS) on the immune system of the mouse-substitution for helper T cells and induction of B-cell mitosis-has been investigated. C3H/HeJ mice are unresponsive and do not produce (as other strains do) antibody to 2,4,6-trinitrophenol (TNP) conjugated with autologous mouse erythrocytes (MRBC-TNP) in the presence of LPS. We found that C3H/HeJ spleen cells produce antibody to MRBC-TNP when (a) LPS and macrophages from LPS-responsive C3HeB/FeJ mice or (b) tumor necrosis serum ([TNS] induced by LPS in responsive mice) are added. The mitotic response was not restored. The findings suggest that adjuvanticity and mitogenicity represent distinct pathways of B-cell activation by LPS, subject to different regulatory mechanisms.

© 1977 Rockefeller University Press
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B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production.
M K Hoffmann, C Galanos, S Koenig, H F Oettgen
Journal of Experimental Medicine Dec 1977, 146 (6) 1640-1647; DOI: 10.1084/jem.146.6.1640

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The Journal of Experimental Medicine: 215 (4)

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April 2, 2018
Volume 215, No. 4

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