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jem Home » 1976 Archive » 1 March » 143 (3): 678
Article

Amyloid-related serum protein SAA in endotoxin-induced amyloidosis of the mink.

R F Anders, K Nordstoga, J B Natvig, G Husby
R F Anders
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K Nordstoga
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J B Natvig
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G Husby
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DOI: 10.1084/jem.143.3.678 | Published March 1, 1976
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Abstract

The concentration of the amyloid AA-related serum protein (SAA) was markedly increased after endotoxin injections in mink, mouse, rabbit, and man. It was particularly studied during the development of endotoxin-induced amyloidosis of the mink. Protein SAA was markedly elevated in all mink 24 h after the first endotoxin injection but had fallen to relatively low levels before the onset of amyloidosis at about 4 wk. These results are consistent with SAA being a circulating precursor of the amyloid fibril protein, AA. However, both proteins may be derived by proteolysis from a common precursor.

© 1976 Rockefeller University Press
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Amyloid-related serum protein SAA in endotoxin-induced amyloidosis of the mink.
R F Anders, K Nordstoga, J B Natvig, G Husby
Journal of Experimental Medicine Mar 1976, 143 (3) 678-683; DOI: 10.1084/jem.143.3.678

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The Journal of Experimental Medicine: 215 (4)

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Volume 215, No. 4

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