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jem Home » 1974 Archive » 1 May » 139 (5): 1084
Article

UPTAKE AND REDUCTION OF OXIDIZED AND REDUCED ASCORBATE BY HUMAN LEUKOCYTES

Robert H. Bigley, Libuse Stankova
Robert H. Bigley
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Libuse Stankova
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DOI: 10.1084/jem.139.5.1084 | Published May 1, 1974
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Abstract

Incubation of human leukocytes with dehydroascorbate (DHA) results in an increase in their reduced ascorbate (AA) content and hexose monophosphate shunt (HMS) activity, independent of oxygen supply. Incubation with AA induces these changes only in the presence of oxygen. The increase in HMS activity observed as cell AA increases by 1 µmol is the same during incubation with either DHA or AA.

We propose that human leukocytes take up ascorbate as DHA (AA after oxidation to DHA) and reduce it promptly to AA, and that HMS stimulation upon incubation with either AA or DHA is a result of DHA reduction.

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    • Submitted: 4 February 1974
© 1974 Rockefeller University Press
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UPTAKE AND REDUCTION OF OXIDIZED AND REDUCED ASCORBATE BY HUMAN LEUKOCYTES
Robert H. Bigley, Libuse Stankova
Journal of Experimental Medicine May 1974, 139 (5) 1084-1092; DOI: 10.1084/jem.139.5.1084

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The Journal of Experimental Medicine: 216 (2)

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February 4, 2019
Volume 216, No. 2

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