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jem Home » 1973 Archive » 1 May » 137 (5): 1142
Article

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

Ralph M. Steinman, Zanvil A. Cohn
Ralph M. Steinman
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Zanvil A. Cohn
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DOI: 10.1084/jem.137.5.1142 | Published May 1, 1973
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Abstract

A novel cell type has been identified in adherent cell populations prepared from mouse peripheral lymphoid organs (spleen, lymph node, Peyer's patch). Though present in small numbers (0.1–1.6% of the total nucleated cells) the cells have distinct morphological features. The nucleus is large, retractile, contorted in shape, and contains small nucleoli (usually two). The abundant cytoplasm is arranged in processes of varying length and width and contains many large spherical mitochondria. In the living state, the cells undergo characteristic movements, and unlike macrophages, do not appear to engage in active endocytosis. The term, dendritic cell, is proposed for this novel cell type.

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    • Submitted: 18 January 1973
© 1973 Rockefeller University Press
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IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE
Ralph M. Steinman, Zanvil A. Cohn
Journal of Experimental Medicine May 1973, 137 (5) 1142-1162; DOI: 10.1084/jem.137.5.1142

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The Journal of Experimental Medicine: 216 (2)

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February 4, 2019
Volume 216, No. 2

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