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jem Home » 1972 Archive » 1 March » 135 (3): 660
Article

RECEPTORS ON IMMUNOCOMPETENT CELLS

Joseph M. Davie, William E. Paul
Joseph M. Davie
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William E. Paul
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DOI: 10.1084/jem.135.3.660 | Published March 1, 1972
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Abstract

During the course of the immune response to dinitrophenylated guinea pig albumin (DNP-GPA), a striking and parallel increase in avidity for ϵ-DNP-L-lysine occurs in the receptors on antigen-binding lymphocytes, antibody secreted by individual plaque-forming cells, and serum antibody molecules. A detailed analysis of the avidity distribution of antibody produced by plaque-forming cells indicates that this "immunologic maturation" is primarily due to a preservation of the high avidity subpopulation and a striking loss in the low avidity population rather than to sequential appearance of these cells.

Moreover, the demonstration of the increased avidity of receptors of antigen-binding lymphocytes, which appear to be precursors of antibody-synthesizing cells, strongly suggests that the antigen-driven selectional process operates primarily on this cell type.

Footnotes

    • Submitted: 21 October 1971
© 1972 Rockefeller University Press
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RECEPTORS ON IMMUNOCOMPETENT CELLS
Joseph M. Davie, William E. Paul
Journal of Experimental Medicine Mar 1972, 135 (3) 660-674; DOI: 10.1084/jem.135.3.660

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The Journal of Experimental Medicine: 215 (4)

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April 2, 2018
Volume 215, No. 4

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