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jem Home » 1970 Archive » 1 November » 132 (5): 845
Article

INDUCTION AND REVERSAL OF IMMUNE PARALYSIS IN VITRO

V. S. Byers, E. E. Sercarz
V. S. Byers
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E. E. Sercarz
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DOI: 10.1084/jem.132.5.845 | Published November 1, 1970
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Abstract

Induction of the immune response can only be completed after antigen is removed from the cellular environment. Primed rabbit lymph node fragments were cultured in vitro with 5 mg/ml BSA. If antigen was removed from the fragments 2 hr later, they produced a normal anti-BSA response, which was first evident 5 days later. If antigen removal was delayed for 3 days, the onset of the response was postponed for 2 to 3 days.

Pulses with BUDR marked the periods of cell proliferation in both sets of cultures, and established that the postponement of antibody production was preceded by a postponement in the wave of proliferation among precursors of antibody forming cells.

The similarity in avidity of antibody-containing fluids from normal and postponed cultures support the idea that the same cell population produced the response in each case.

It was concluded that a reversible state of paralysis could be instituted in antigen-responsive cells, and this state did not depend upon cell-killing. The widespread incidence of temporary paralysis as an early aspect of the immune response was discussed.

Footnotes

    • Submitted: 14 May 1970
© 1970 Rockefeller University Press
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INDUCTION AND REVERSAL OF IMMUNE PARALYSIS IN VITRO
V. S. Byers, E. E. Sercarz
Journal of Experimental Medicine Nov 1970, 132 (5) 845-857; DOI: 10.1084/jem.132.5.845

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The Journal of Experimental Medicine: 215 (4)

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April 2, 2018
Volume 215, No. 4

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