Four strains of Group A streptococci, possessing different degrees of virulence for both mice and rats, were tested for susceptibility to phagocytosis on glass slides, in glass roller tubes, and on the surfaces of freshly excised tissues and moistened filter paper. All of the tests were performed in the absence of serum to exclude the possible presence of opsonins. Only under conditions which allowed surface phagocytosis to take place was there a correlation between virulence and susceptibility to phagocytosis. A similar relationship between virulence and surface phagocytosis was also demonstrable in vivo during the early stages of experimental streptococcal peritonitis. Systematic study of the evolution of the peritonitis revealed that its outcome was determined by the phagocytic reaction which occurred in the first few hours of the infection.
Article|
October 01 1959
STUDIES ON THE PATHOGENICITY OF GROUP A STREPTOCOCCI : I. ITS RELATION TO SURFACE PHAGOCYTOSIS
Marie Judith Foley,
Marie Judith Foley
From the Department of Microbiology, Johns Hopkins University School of Medicine and School of Hygiene and Public Health, Baltimore
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Mary Ruth Smith,
Mary Ruth Smith
From the Department of Microbiology, Johns Hopkins University School of Medicine and School of Hygiene and Public Health, Baltimore
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W. Barry Wood, Jr.
W. Barry Wood, Jr.
From the Department of Microbiology, Johns Hopkins University School of Medicine and School of Hygiene and Public Health, Baltimore
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Marie Judith Foley
From the Department of Microbiology, Johns Hopkins University School of Medicine and School of Hygiene and Public Health, Baltimore
Mary Ruth Smith
From the Department of Microbiology, Johns Hopkins University School of Medicine and School of Hygiene and Public Health, Baltimore
W. Barry Wood, Jr.
From the Department of Microbiology, Johns Hopkins University School of Medicine and School of Hygiene and Public Health, Baltimore
Received:
June 29 1959
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1959, by The Rockefeller Institute
1959
J Exp Med (1959) 110 (4): 603–616.
Article history
Received:
June 29 1959
Citation
Marie Judith Foley, Mary Ruth Smith, W. Barry Wood; STUDIES ON THE PATHOGENICITY OF GROUP A STREPTOCOCCI : I. ITS RELATION TO SURFACE PHAGOCYTOSIS . J Exp Med 1 October 1959; 110 (4): 603–616. doi: https://doi.org/10.1084/jem.110.4.603
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