Mucosal Immunology

Mucosal Immunology

Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration
Yousef R. Badran, Fatma Dedeoglu, Juan Manuel Leyva Castillo, Wayne Bainter, Toshiro K. Ohsumi, Athos Bousvaros, Jeffrey D. Goldsmith, Raif S. Geha, Janet Chou

Journal of Experimental Medicine Jul 2017, 214 (7) 1937-1947; DOI: 10.1084/jem.20160724
Thymic progenitors of TCRαβ⁺ CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development
Dominic P. Golec, Romy E. Hoeppli, Laura M. Henao Caviedes, Jillian McCann, Megan K. Levings, Troy A. Baldwin

Journal of Experimental Medicine Jun 2017, jem.20170844; DOI: 10.1084/jem.20170844
Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome
Viola Neudecker, Moritz Haneklaus, Owen Jensen, Ludmila Khailova, Joanne C. Masterson, Hazel Tye, Kathryn Biette, Paul Jedlicka, Kelley S. Brodsky, Mark E. Gerich, Matthias Mack, Avril A.B. Robertson, Matthew A. Cooper, Glenn T. Furuta, Charles A. Dinarello, Luke A. O’Neill, Holger K. Eltzschig, Seth L. Masters, Eóin N. McNamee

Journal of Experimental Medicine Jun 2017, 214 (6) 1737-1752; DOI: 10.1084/jem.20160462
Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths
Victoria S. Pelly, Stephanie M. Coomes, Yashaswini Kannan, Manolis Gialitakis, Lewis J. Entwistle, Jimena Perez-Lloret, Stephanie Czieso, Isobel S. Okoye, Dominik Rückerl, Judith E. Allen, Frank Brombacher, Mark S. Wilson

Journal of Experimental Medicine Jun 2017, 214 (6) 1809-1826; DOI: 10.1084/jem.20161104
IL-22BP dictates characteristics of Peyer’s patch follicle-associated epithelium for antigen uptake
Toshi Jinnohara, Takashi Kanaya, Koji Hase, Sayuri Sakakibara, Tamotsu Kato, Naoko Tachibana, Takaharu Sasaki, Yusuke Hashimoto, Toshiro Sato, Hiroshi Watarai, Jun Kunisawa, Naoko Shibata, Ifor R. Williams, Hiroshi Kiyono, Hiroshi Ohno

Journal of Experimental Medicine Jun 2017, 214 (6) 1607-1618; DOI: 10.1084/jem.20160770
Tissue adaptation: Implications for gut immunity and tolerance
Ana M.C. Faria, Bernardo S. Reis, Daniel Mucida

Journal of Experimental Medicine May 2017, 214 (5) 1211-1226; DOI: 10.1084/jem.20162014
Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection
Amanda J. Lee, Branson Chen, Marianne V. Chew, Nicole G. Barra, Mira M. Shenouda, Tina Nham, Nico van Rooijen, Manel Jordana, Karen L. Mossman, Robert D. Schreiber, Matthias Mack, Ali A. Ashkar

Journal of Experimental Medicine Apr 2017, 214 (4) 1153-1167; DOI: 10.1084/jem.20160880
IKKα controls ATG16L1 degradation to prevent ER stress during inflammation
Michaela A. Diamanti, Jalaj Gupta, Moritz Bennecke, Tiago De Oliveira, Mallika Ramakrishnan, Anne K. Braczynski, Benjamin Richter, Petra Beli, Yinling Hu, Maya Saleh, Michel Mittelbronn, Ivan Dikic, Florian R. Greten

Journal of Experimental Medicine Feb 2017, 214 (2) 423-437; DOI: 10.1084/jem.20161867
Antibody-secreting plasma cells persist for decades in human intestine
Ole J.B. Landsverk, Omri Snir, Raquel Bartolomé Casado, Lisa Richter, Jeff E. Mold, Pedro Réu, Rune Horneland, Vemund Paulsen, Sheraz Yaqub, Einar Martin Aandahl, Ole M. Øyen, Hildur Sif Thorarensen, Mehran Salehpour, Göran Possnert, Jonas Frisén, Ludvig M. Sollid, Espen S. Baekkevold, Frode L. Jahnsen

Journal of Experimental Medicine Feb 2017, 214 (2) 309-317; DOI: 10.1084/jem.20161590
Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s
Jakob von Moltke, Claire E. O’Leary, Nora A. Barrett, Yoshihide Kanaoka, K. Frank Austen, Richard M. Locksley

Journal of Experimental Medicine Jan 2017, 214 (1) 27-37; DOI: 10.1084/jem.20161274

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