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Vol. 204, No. 3, March 19, 2007. Pages 583–594.

The authors regret that an error appeared in the third paragraph under the subheading "Prx II negatively modulates NF-B activation and the phosphorylation of MAPK pathway kinases in response to LPS." In the sentence, "lower" should have read "higher." The corrected sentence appears below:

Consistent with the findings in Fig. 3 C, primary BMDMs from Prx II-deficient mice showed higher activation of MAPKs, which included JNK, ERK 1/2, and p38, than the primary BMDMs from WT mice, although the kinetics of activation during LPS treatment were similar for cells for the two types of mice (Fig. 3 D).

In addition, the rule below "+ LPS" in Fig. 4 A should have extended over lane 2. The corrected figure is shown below.

View larger version (50K): [in this window] [in a new window] [Download PPT slide]   Figure 4. Endogenous ROS induced by NADPH oxidase is specifically involved in LPS signaling and proinflammatory responses in Prx II–deficient cells. (A) After preincubation for 30 min with 10 and 30 mM NAC, 10 and 20 µM DPI, 10 and 100 µM allopurinol, 1 and 10 µM rotenone, 100 and 500 µM L-NMMA, or 100 and 500 µM L-NAME, BMDMs were stimulated with 1 µg/ml LPS for 30 min. The cells were harvested and subjected to Western blot analysis for IB, phosphorylated ERK 1/2, and p38 MAPK. The same blots were washed and blotted for ß-actin as the loading control. Data shown are representative of three independent experiments that gave similar results. (B) The experimental conditions followed the pattern outlined in A. Culture supernatants were harvested after stimulation with LPS for 18 h, and the TNF- and IL-6 expression levels were measured by ELISA. Data shown are the mean ± SD of three experiments. *, P < 0.05; **, P < 0.01; and ***, P < 0.001 compared with WT cell cultures stimulated with LPS. MC, media control.

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This Article Full Text (PDF, 615K) PPT slides of all figures Alert me when this article is cited Services Email this article Similar articles in this journal Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Yang, C.-S. Articles by Jo, E.-K. Search for Related Content PubMed Articles by Yang, C.-S. Articles by Jo, E.-K. Social Bookmarking                            What's this?