Figure 4. IgV_H sequences and mutations therein of related IgM and IgG clones found within individual GCs of LNs 1, 2, and 3. Lollipop-shaped symbols indicate nucleotide differences as compared with the respective germline IgV_H genes. Replacement and silent mutations are indicated by closed and open circles, respectively. Gray shaded bars covering mutations of IgM and IgG clones indicate identical mutations. The total number of clones in which a particular IgV_H mutation pattern was found is indicated by (Nx).