A rush to judgment on Th17

doi:10.1084/jem.20072066

Published online
doi:10.1084/jem.20072066
The Journal of Experimental Medicine, Vol. 205, No. 7, 1517-1522
The Rockefeller University Press, 0022-1007 $30.00
© Steinman

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COMMENTARY

A rush to judgment on Th17

Lawrence Steinman

L.S. is at Department of Neurology and Neurological Sciences and the Interdepartmental Program in Immunology, Beckman Center for Molecular Medicine, Stanford University, Stanford, CA 94305

CORRESPONDENCE L.S.: steinman{at}stanford.edu

ABSTRACT
Some immunologists have characterized T helper (Th)17 T cellsas the master mediators of tissue damage in a variety of pathologicalconditions. New data now demonstrate that Th1 and Th17 T cellsare independently capable of inducing disease in two establishedmodels of autoimmunity. Thus, the role of Th17 cytokines asthe central mediators of pathological tissue damage seems torequire clarification.

© 2008 Steinman This article is distributed under the termsof an Attribution–Noncommercial–Share Alike–NoMirror Sites license for the first six months after the publicationdate (see http://www.jem.org/misc/terms.shtml). After six monthsit is available under a Creative Commons License (Attribution–Noncommercial–ShareAlike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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