The Journal of Experimental Medicine
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Published online
doi:10.1084/jem.20081057
The Journal of Experimental Medicine, Vol. 205, No. 6, 1251-1254
The Rockefeller University Press, 0022-1007 $30.00
© Tarlinton
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COMMENTARY

 Sheepish B cells: evidence for antigen-independent antibody diversification in humans and mice

David Tarlinton

D.T. is at The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria 3050, Australia

CORRESPONDENCE D.T.: tarlinton{at}wehi.edu.au


ABSTRACT
Antibody diversity is first generated by rearrangement of immunoglobulin (Ig) genes during B cell development in the bone marrow, and later by antigen-driven diversification in germinal centers (GCs). New data in humans and mice now identify specific B cell populations that may have undergone antigen-independent hypermutation outside GCs.

© 2008 Tarlinton This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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