Alarming dendritic cells for Th2 induction

doi:10.1084/jem.20072665

Published online
doi:10.1084/jem.20072665
The Journal of Experimental Medicine, Vol. 205, No. 1, 13-17
The Rockefeller University Press, 0022-1007 $30.00
© MacDonald et al.

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Alarming dendritic cells for Th2 induction

Andrew S. MacDonald and Rick M. Maizels

A.S. MacDonald and R.M. Maizels are at the Institute of Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK

CORRESPONDENCE R.M.M.: rick.maizels{at}ed.ac.uk OR A.S.M.: andrew.macdonald{at}ed.ac.uk

ABSTRACT
There is an ever-increasing understanding of the mechanismsby which pathogens such as bacteria, viruses, and protozoa activatedendritic cells (DCs) to drive T helper type 1 (Th1) responses,but we know much less about how these cells elicit Th2 responses.This gap in our knowledge puts us at a distinct disadvantagein designing therapeutics for certain immune-mediated diseases.However, progress is being made with the identification of novelendogenous tissue factors that can enhance Th2 induction byDCs.

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