Are hemostasis and thrombosis two sides of the same coin?

doi:10.1084/jem.20060217

Published online 13 March 2006 doi:10.1084/jem.20060217
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 3, 493-495

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COMMENTARY

Are hemostasis and thrombosis two sides of the same coin?

Robert W. Colman

R.W.C. is at Sol Sherry Thrombosis Research Center and Hematology Division, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140.

CORRESPONDENCE R.W.C.: colmanr{at}temple.edu

Abstract
Factor XII (FXII), a clotting enzyme that can initiate coagulationin vitro, has long been considered dispensable for normal bloodclotting in vivo because hereditary deficiencies in FXII arenot associated with spontaneous or excessive bleeding. However,new studies show that mice lacking FXII are protected againstarterial thrombosis (obstructive clot formation) and stroke.Thus, FXII could be a unique drug target that could be blockedto prevent thrombosis without the side effect of increased bleeding.

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