Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 1250K) PPT slides of all figures Supplemental Material Index Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Annacker, O. Articles by Powrie, F. Search for Related Content PubMed PubMed Citation Articles by Annacker, O. Articles by Powrie, F. Related Collections Related Articles Social Bookmarking                            What's this?

¹ Sir William Dunn School of Pathology, University of Oxford, OX1 3RE, England, UK
² Unit of Rheumatology, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden
³ Celltech R&D Limited, Slough, SL1 3WE, England, UK
⁴ Immunology Section, Biomedical Center I-13, S-221 84, Lund, Sweden
⁵ Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115

CORRESPONDENCE Fiona Powrie: fiona.powrie{at}pathology.ox.ac.uk

The integrin CD103 is highly expressed at mucosal sites, but its role in mucosal immune regulation remains poorly understood. We have analyzed the functional role of CD103 in intestinal immune regulation using the T cell transfer model of colitis. Our results show no mandatory role for CD103 expression on T cells for either the development or CD4⁺CD25⁺ regulatory T (T reg) cell–mediated control of colitis. However, wild-type CD4⁺CD25⁺ T cells were unable to prevent colitis in immune-deficient recipients lacking CD103, demonstrating a nonredundant functional role for CD103 on host cells in T reg cell–mediated intestinal immune regulation. Non–T cell expression of CD103 is restricted primarily to CD11c^highMHC class II^high dendritic cells (DCs). This DC population is present at a high frequency in the gut-associated lymphoid tissue and appears to mediate a distinct functional role. Thus, CD103⁺ DCs, but not their CD103^– counterparts, promoted expression of the gut-homing receptor CCR9 on T cells. Conversely, CD103^– DCs promoted the differentiation of IFN-–producing T cells. Collectively, these data suggest that CD103⁺ and CD103^– DCs represent functionally distinct subsets and that CD103 expression on DCs influences the balance between effector and regulatory T cell activity in the intestine.

C.M. Parker's present address is Harvard Medical School, Office of Research, Boston, MA 02459.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

Related Articles

Functional specialization of gut CD103⁺ dendritic cells in the regulation of tissue-selective T cell homing

Bengt Johansson-Lindbom, Marcus Svensson, Oliver Pabst, Caroline Palmqvist, Gabriel Marquez, Reinhold Förster, and William W. Agace
J. Exp. Med. 2005 202: 1063-1073. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

• Molenaar, R., Greuter, M., van der Marel, A. P. J., Roozendaal, R., Martin, S. F., Edele, F., Huehn, J., Forster, R., O'Toole, T., Jansen, W., Eestermans, I. L., Kraal, G., Mebius, R. E. (2009). Lymph Node Stromal Cells Support Dendritic Cell-Induced Gut-Homing of T Cells. J. Immunol. 183: 6395-6402 [Abstract] [Full Text]  
• Lahl, K., Mayer, C. T., Bopp, T., Huehn, J., Loddenkemper, C., Eberl, G., Wirnsberger, G., Dornmair, K., Geffers, R., Schmitt, E., Buer, J., Sparwasser, T. (2009). Nonfunctional Regulatory T Cells and Defective Control of Th2 Cytokine Production in Natural Scurfy Mutant Mice. J. Immunol. 183: 5662-5672 [Abstract] [Full Text]  
• Sharma, R., Sung, S.-s. J., Abaya, C. E., Ju, A. C.-Y., Fu, S. M., Ju, S.-T. (2009). IL-2 Regulates CD103 Expression on CD4+ T Cells in Scurfy Mice that Display Both CD103-Dependent and Independent Inflammation. J. Immunol. 183: 1065-1073 [Abstract] [Full Text]  
• Dunne, P. J., Moran, B., Cummins, R. C., Mills, K. H. G. (2009). CD11c+CD8{alpha}+ Dendritic Cells Promote Protective Immunity to Respiratory Infection with Bordetella pertussis. J. Immunol. 183: 400-410 [Abstract] [Full Text]  
• Lin, Y.-C., Chang, L.-Y., Huang, C.-T., Peng, H.-M., Dutta, A., Chen, T.-C., Yeh, C.-T., Lin, C.-Y. (2009). Effector/Memory but Not Naive Regulatory T Cells Are Responsible for the Loss of Concomitant Tumor Immunity. J. Immunol. 182: 6095-6104 [Abstract] [Full Text]  
• Qiu, C.-H., Miyake, Y., Kaise, H., Kitamura, H., Ohara, O., Tanaka, M. (2009). Novel Subset of CD8{alpha}+ Dendritic Cells Localized in the Marginal Zone Is Responsible for Tolerance to Cell-Associated Antigens. J. Immunol. 182: 4127-4136 [Abstract] [Full Text]  
• Guerrero-Plata, A., Kolli, D., Hong, C., Casola, A., Garofalo, R. P. (2009). Subversion of Pulmonary Dendritic Cell Function by Paramyxovirus Infections. J. Immunol. 182: 3072-3083 [Abstract] [Full Text]  
• Vogtenhuber, C., O'Shaughnessy, M. J., Vignali, D. A. A., Blazar, B. R. (2008). Outgrowth of CD4low/negCD25+ T Cells with Suppressor Function in CD4+CD25+ T Cell Cultures upon Polyclonal Stimulation Ex Vivo. J. Immunol. 181: 8767-8775 [Abstract] [Full Text]  
• Edele, F., Molenaar, R., Gutle, D., Dudda, J. C., Jakob, T., Homey, B., Mebius, R., Hornef, M., Martin, S. F. (2008). Cutting Edge: Instructive Role of Peripheral Tissue Cells in the Imprinting of T Cell Homing Receptor Patterns. J. Immunol. 181: 3745-3749 [Abstract] [Full Text]  
• Jaensson, E., Uronen-Hansson, H., Pabst, O., Eksteen, B., Tian, J., Coombes, J. L., Berg, P.-L., Davidsson, T., Powrie, F., Johansson-Lindbom, B., Agace, W. W. (2008). Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. JEM 205: 2139-2149 [Abstract] [Full Text]  
• Alford, S. K., Longmore, G. D., Stenson, W. F., Kemper, C. (2008). CD46-Induced Immunomodulatory CD4+ T Cells Express the Adhesion Molecule and Chemokine Receptor Pattern of Intestinal T Cells. J. Immunol. 181: 2544-2555 [Abstract] [Full Text]  
• Schlickum, S., Sennefelder, H., Friedrich, M., Harms, G., Lohse, M. J., Kilshaw, P., Schon, M. P. (2008). Integrin {alpha}E(CD103){beta}7 influences cellular shape and motility in a ligand-dependent fashion. Blood 112: 619-625 [Abstract] [Full Text]  
• Sehrawat, S., Suvas, S., Sarangi, P. P., Suryawanshi, A., Rouse, B. T. (2008). In Vitro-Generated Antigen-Specific CD4+ CD25+ Foxp3+ Regulatory T Cells Control the Severity of Herpes Simplex Virus-Induced Ocular Immunoinflammatory Lesions. J. Virol. 82: 6838-6851 [Abstract] [Full Text]  
• Adams, D H, Eksteen, B, Curbishley, S M (2008). Immunology of the gut and liver: a love/hate relationship. Gut 57: 838-848 [Full Text]  
• Sehrawat, S., Rouse, B. T. (2008). Anti-Inflammatory Effects of FTY720 against Viral-Induced Immunopathology: Role of Drug-Induced Conversion of T Cells to Become Foxp3+ Regulators. J. Immunol. 180: 7636-7647 [Abstract] [Full Text]  
• Elgueta, R., Sepulveda, F. E., Vilches, F., Vargas, L., Mora, J. R., Bono, M. R., Rosemblatt, M. (2008). Imprinting of CCR9 on CD4 T Cells Requires IL-4 Signaling on Mesenteric Lymph Node Dendritic Cells. J. Immunol. 180: 6501-6507 [Abstract] [Full Text]  
• Jakubzick, C., Tacke, F., Ginhoux, F., Wagers, A. J., van Rooijen, N., Mack, M., Merad, M., Randolph, G. J. (2008). Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103- Pulmonary Dendritic Cell Populations. J. Immunol. 180: 3019-3027 [Abstract] [Full Text]  
• Ho, J., Kurtz, C. C., Naganuma, M., Ernst, P. B., Cominelli, F., Rivera-Nieves, J. (2008). A CD8+/CD103high T Cell Subset Regulates TNF-Mediated Chronic Murine Ileitis. J. Immunol. 180: 2573-2580 [Abstract] [Full Text]  
• MacDonald, A. S., Maizels, R. M. (2008). Alarming dendritic cells for Th2 induction. JEM 205: 13-17 [Abstract] [Full Text]  
• Brem-Exner, B. G., Sattler, C., Hutchinson, J. A., Koehl, G. E., Kronenberg, K., Farkas, S., Inoue, S., Blank, C., Knechtle, S. J., Schlitt, H. J., Fandrich, F., Geissler, E. K. (2008). Macrophages Driven to a Novel State of Activation Have Anti-Inflammatory Properties in Mice. J. Immunol. 180: 335-349 [Abstract] [Full Text]  
• Yamazaki, S., Bonito, A. J., Spisek, R., Dhodapkar, M., Inaba, K., Steinman, R. M. (2007). Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors. Blood 110: 4293-4302 [Abstract] [Full Text]  
• De Luca, A., Montagnoli, C., Zelante, T., Bonifazi, P., Bozza, S., Moretti, S., D'Angelo, C., Vacca, C., Boon, L., Bistoni, F., Puccetti, P., Fallarino, F., Romani, L. (2007). Functional yet Balanced Reactivity to Candida albicans Requires TRIF, MyD88, and IDO-Dependent Inhibition of Rorc. J. Immunol. 179: 5999-6008 [Abstract] [Full Text]  
• Lacy-Hulbert, A., Smith, A. M., Tissire, H., Barry, M., Crowley, D., Bronson, R. T., Roes, J. T., Savill, J. S., Hynes, R. O. (2007). Ulcerative colitis and autoimmunity induced by loss of myeloid {alpha}v integrins. Proc. Natl. Acad. Sci. USA 104: 15823-15828 [Abstract] [Full Text]  
• Iliev, I. D., Matteoli, G., Rescigno, M. (2007). The yin and yang of intestinal epithelial cells in controlling dendritic cell function. JEM 204: 2253-2257 [Abstract] [Full Text]  
• Coombes, J. L., Siddiqui, K. R.R., Arancibia-Carcamo, C. V., Hall, J., Sun, C.-M., Belkaid, Y., Powrie, F. (2007). A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-{beta} and retinoic acid dependent mechanism. JEM 204: 1757-1764 [Abstract] [Full Text]  
• Sun, C.-M., Hall, J. A., Blank, R. B., Bouladoux, N., Oukka, M., Mora, J. R., Belkaid, Y. (2007). Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. JEM 204: 1775-1785 [Abstract] [Full Text]  
• Benson, M. J., Pino-Lagos, K., Rosemblatt, M., Noelle, R. J. (2007). All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. JEM 204: 1765-1774 [Abstract] [Full Text]  
• Pyzik, M., Piccirillo, C. A. (2007). TGF-{beta}1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets. J. Leukoc. Biol. 82: 335-346 [Abstract] [Full Text]  
• Takenaka, S., Safroneeva, E., Xing, Z., Gauldie, J. (2007). Dendritic Cells Derived from Murine Colonic Mucosa Have Unique Functional and Phenotypic Characteristics. J. Immunol. 178: 7984-7993 [Abstract] [Full Text]  
• del Rio, M.-L., Rodriguez-Barbosa, J.-I., Kremmer, E., Forster, R. (2007). CD103- and CD103+ Bronchial Lymph Node Dendritic Cells Are Specialized in Presenting and Cross-Presenting Innocuous Antigen to CD4+ and CD8+ T Cells. J. Immunol. 178: 6861-6866 [Abstract] [Full Text]  
• Stephens, G. L., Andersson, J., Shevach, E. M. (2007). Distinct Subsets of FoxP3+ Regulatory T Cells Participate in the Control of Immune Responses. J. Immunol. 178: 6901-6911 [Abstract] [Full Text]  
• Huibregtse, I L, van Lent, A U, van Deventer, S J H (2007). Immunopathogenesis of IBD: insufficient suppressor function in the gut?. Gut 56: 584-592 [Full Text]  
• Floc'h, A. L., Jalil, A., Vergnon, I., Chansac, B. L. M., Lazar, V., Bismuth, G., Chouaib, S., Mami-Chouaib, F. (2007). {alpha}E{beta}7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis. JEM 204: 559-570 [Abstract] [Full Text]  
• Nguyen, V. H., Zeiser, R., daSilva, D. L., Chang, D. S., Beilhack, A., Contag, C. H., Negrin, R. S. (2007). In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation. Blood 109: 2649-2656 [Abstract] [Full Text]  
• Ling, K.-L., Dulphy, N., Bahl, P., Salio, M., Maskell, K., Piris, J., Warren, B. F., George, B. D., Mortensen, N. J., Cerundolo, V. (2007). Modulation of CD103 Expression on Human Colon Carcinoma-Specific CTL. J. Immunol. 178: 2908-2915 [Abstract] [Full Text]  
• Beaty, S. R., Rose, C. E. Jr., Sung, S.-s. J. (2007). Diverse and Potent Chemokine Production by Lung CD11bhigh Dendritic Cells in Homeostasis and in Allergic Lung Inflammation. J. Immunol. 178: 1882-1895 [Abstract] [Full Text]  
• Hintzen, G., Ohl, L., del Rio, M.-L., Rodriguez-Barbosa, J.-I., Pabst, O., Kocks, J. R., Krege, J., Hardtke, S., Forster, R. (2006). Induction of Tolerance to Innocuous Inhaled Antigen Relies on a CCR7-Dependent Dendritic Cell-Mediated Antigen Transport to the Bronchial Lymph Node. J. Immunol. 177: 7346-7354 [Abstract] [Full Text]  
• Wei, S., Kryczek, I., Zou, W. (2006). Regulatory T-cell compartmentalization and trafficking. Blood 108: 426-431 [Abstract] [Full Text]  
• Chae, W.-J., Henegariu, O., Lee, S.-K., Bothwell, A. L. M. (2006). The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc. Natl. Acad. Sci. USA 103: 9631-9636 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS