The Journal of Experimental Medicine
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Published 7 February 2005. doi:10.1084/jem.20050080
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 3, 321-323
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Bacterial toxins and the immune system : show me the in vivo targets



Jorge E. Galán

J.E.G. is at Yale University School of Medicine, New Haven, CT 06536

CORRESPONDENCE J.E.G.: jorge.galan{at}yale.edu


Abstract
Microorganisms that cause persistent infection often exhibit specific adaptations that allow them to avoid the adaptive immune response. Recently, several bacterial toxins have been shown in vitro to disrupt immune cell functions. However, it remains to be established whether these activities are relevant during infection and whether these toxins have specifically evolved to disrupt the adaptive immune system.



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