The Journal of Experimental Medicine
Avanti Polar Lipids, Inc.
  Home | Help | Feedback | Subscriptions | Archive | Search | Latest Articles
Published online
doi:10.1084/jem.20080720
The Journal of Experimental Medicine
The Rockefeller University Press, 0022-1007 $30.00
© Zaph et al.
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 1518K)
Right arrow PPT slides of all figures
Right arrow Supplemental Material Index
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zaph, C.
Right arrow Articles by Artis, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zaph, C.
Right arrow Articles by Artis, D.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

BRIEF DEFINITIVE REPORT

 Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

Colby Zaph1, Yurong Du1, Steven A. Saenz1, Meera G. Nair1, Jacqueline G. Perrigoue1, Betsy C. Taylor1, Amy E. Troy1, Dmytro E. Kobuley2, Robert A. Kastelein3, Daniel J. Cua3, Yimin Yu2, and David Artis1

1 Department of Pathobiology and 2 Department of Biology, University of Pennsylvania, Philadelphia, PA 19104
3 Discovery Research, Schering-Plough Biopharma, Palo Alto, CA 94304

CORRESPONDENCE David Artis: dartis{at}vet.upenn.edu OR Colby Zaph: colby{at}brc.ubc.ca

Alterations in the composition of intestinal commensal bacteria are associated with enhanced susceptibility to multiple inflammatory diseases, including those conditions associated with interleukin (IL)-17–producing CD4+ T helper (Th17) cells. However, the relationship between commensal bacteria and the expression of proinflammatory cytokines remains unclear. Using germ-free mice, we show that the frequency of Th17 cells in the large intestine is significantly elevated in the absence of commensal bacteria. Commensal-dependent expression of the IL-17 family member IL-25 (IL-17E) by intestinal epithelial cells limits the expansion of Th17 cells in the intestine by inhibiting expression of macrophage-derived IL-23. We propose that acquisition of, or alterations in, commensal bacteria influences intestinal immune homeostasis via direct regulation of the IL-25–IL-23–IL-17 axis.

C. Zaph's present address is The Biomedical Research Centre, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

© 2008 Zaph et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search