ARTICLE

Jean Oliver M.D.¹, Muriel MacDowell ¹, and Yin Chen Lee M.D.¹

¹ From the Department of Pathology, State University of New York, Medical Center at New York City, and the Renal Research Unit, Overlook Hospital, Summit, New Jersey

When proteins pass the glomerular filter they are in part directly absorbed by the epithelial cells of the proximal convolution of the nephron with no apparent alteration of the cytological pattern. If the capacity of the tubule cells to thus absorb protein from the tubule fluid is exceeded either by the amount or the nature of the protein the accessory mechanism of droplet formation occurs. This accessory mechanism is an intracellular process in which cytoplasmic elements, the mitochondria with their enzymes, and the absorbed protein combine to form droplets. As the droplets form and then disappear from the renal cells their evolution presents a constantly changing picture depending on the varying nature of their protein and cytoplasmic content.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• De Rijk, E. P.C.T., Ravesloot, W. T.M., Wijnands, Y., Van Esch, E. (2003). A Fast Histochemical Staining Method to Identify Hyaline Droplets in the Rat Kidney. Toxicol Pathol 31: 462-464 [Abstract]  
• Short, B. G., Burnett, V. L., Swenberg, J. A. (1986). Histopathology and Cell Proliferation Induced by 2,2,4-Trimethylpentane in the Male Rat Kidney. Toxicol Pathol 14: 194-203 [Abstract]  
• ADAMS, D. A. (1960). The Pathophysiology of the Nephrotic Syndrome. Arch Intern Med 106: 117-142 [Abstract]  
• SELLERS, A. L. (1956). The Mechanism and Significance of Protein Excretion by the Normal Kidney. Arch Intern Med 98: 801-806 [Abstract]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS