The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 98, 13-20, Copyright, 1953, by The Rockefeller Institute for Medical Research New York

ARTICLE

A HISTOLOGICAL STUDY OF INFECTIOUS CANINE HEPATITIS BY MEANS OF FLUORESCENT ANTIBODY

David L. Coffin V.M.D.1, Albert H. Coons M.D.1, and Victor J. Cabasso Sc.D.1

1 From the Department of Pathology, Angell Memorial Animal Hospital, Boston; the Departments of Pathology and of Bacteriology and Immunology, Harvard Medical School, Boston; and the Lederle Laboratories Division of the American Cyanamid Company, Pearl River

A study of experimental infectious canine hepatitis in dogs by means of specific fluorescent antibody indicates that the intranuclear inclusions of this disease contain high concentrations of viral antigen.

The increase in virus in the nuclei, as indicated by the accumulation of specific antigenic material, begins on the nuclear membrane and spreads from there to the interior of the nucleus, with the gradual formation of larger granules. Subsequently there appear the homogeneous inclusion bodies characteristic of this infection.

 Submitted on March 19, 1953


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