The Journal of Experimental Medicine
Power up your violet laser
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 419K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ackermann, W. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ackermann, W. W.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
The Journal of Experimental Medicine, Vol 93, 635-642, Copyright, 1951, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE RELATION OF THE KREBS CYCLE TO VIRAL SYNTHESIS : II. THE EFFECT OF SODIUM FLUOROACETATE ON THE PROPAGATION OF INFLUENZA VIRUS IN MICE



W. W. Ackermann Ph.D.1 and With the Technical Assistance of Elaine Kleinschmidt and Hilda Kurtz

1 From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor

A further study has been made of the relationship of reactions of the Krebs cycle to the propagation of influenza virus. By the administration of sublethal doses of sodium fluoroacetate which were found to increase the concentration of citrate in the mouse lung, it was possible to demonstrate a blocking of the citric acid cycle in that organ. Further, the intraperitoneal administration of these concentrations of fluoroacetate was found to inhibit markedly the propagation of influenza, Type A, virus in the lungs of mice.

The inhibition was observed when the fluoroacetate was administered 15 minutes, 6 hours, or 12 hours after the mice were inoculated with virus. This effect was also demonstrable when the concentration of the viral inoculum was varied over a range of virus titers from 103.5 to 106.5.

Sodium fluoroacetate was found to have no effect in vitro on the infectivity or hemagglutinating property of the virus.

The significance of these findings with regard to chemotherapy and to the mechanism of viral synthesis is described.

 Submitted on March 14, 1951


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS