The Journal of Experimental Medicine
Torrey Pines Biolabs
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 847K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Melnick, J. L.
Right arrow Articles by Horstmann, D. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Melnick, J. L.
Right arrow Articles by Horstmann, D. M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
The Journal of Experimental Medicine, Vol 85, 287-303, Copyright, 1947, by The Rockefeller Institute for Medical Research New York

ARTICLE

ACTIVE IMMUNITY TO POLIOMYELITIS IN CHIMPANZEES FOLLOWING SUBCLINICAL INFECTION

Joseph L. Melnick Ph.D.1 and Dorothy M. Horstmann M.D.1

1 From the Section of Preventive Medicine, Yale University Schoo of Medicine, New Haven

This report is concerned with the production of subclinical poliomyelitis in the chimpanzee, and immunity to such infection. Subclinical infection was produced in eight chimpanzees by the administration of virus orally or intracutaneously, and was measured by the production of a virus carrier state and the development of neutralizing antibodies. Immunity was tested by attempting to induce the carrier state again by a challenge dose of virus by the same routes.

With an homologous strain as the challenge virus, immunity as defined here was produced in each of four chimpanzees tested. Neutralizing antibodies to the homologous strain were present about 1 month following the first exposure to virus by either the oral or cutaneous route.

In another group of two chimpanzees, one developed neutralizing antibodies and immunity to heterologous strains, and one did not.

 Submitted on November 29, 1946


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS