The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 85, 227-230, Copyright, 1947, by The Rockefeller Institute for Medical Research New York

ARTICLE

ANTIBODY FORMATION IN MEN FOLLOWING INJECTION OF FOUR TYPE-SPECIFIC POLYSACCHARIDES OF PNEUMOCOCCUS

Michael Heidelberger Ph.D.1, Colin M. MacLeod M.D.1, Richard G. Hodges M.D.1, William G. Bernhard M.D.1, and Marie M. di Lapi 1

1 From the Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, the Department of Bacteriology, New York University College of Medicine, New York, and the Army Air Force Rheumatic Fever Laboratory, Sioux Falls

1. Random selections of the sera of trainees injected 2 months previously with the specific polysaccharides of Types I, II, V, and VII pneumococci contained quantities of antibody to Types I, II, and VII sufficient to account for the favorable results of the immunization procedure.

2. As in earlier studies, the levels of the antibody for the C polysaccharide remained relatively constant before and after the injections.

3. The serum from the preliminary bleedings often contained antibody to the Type VII polysaccharide. This remained relatively constant in a control group injected with saline.

 Submitted on November 18, 1946


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