THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS

doi:10.1084/jem.85.1.117

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The Journal of Experimental Medicine, Vol 85, 117-130, Copyright, 1947, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS

Elvin A. Kabat Ph.D.¹, Abner Wolf M.D.¹, and Ada E. Bezer ¹

¹ From the Departments of Neurology and Pathology, College of Physicians and Surgeons, Columbia University and the Neurological Institute, New York

1. A picture resembling acute disseminated encephalomyelitisin the human being has been regularly and rapidly produced inrhesus monkeys by injection of emulsions of adult rabbit andmonkey brain administered with adjuvants.

2. No lesions of thecentral nervous system resulted from injection of similar emulsionsof fetal rabbit brain or adult rabbit lung.

3. A descriptionof the gross and histological findings in the central nervoussystem is given and compared with features of human demyelinatingdisease.

4. The experimental findings are in accord with thehypothesis that antibody to the injected brain emulsion reactswith the tissues of the nervous system of the animal to producethe pathological changes.

Submitted on July 31, 1946

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