The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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The Journal of Experimental Medicine, Vol 59, 269-282, Copyright, 1934, by The Rockefeller Institute for Medical Research New York

ARTICLE

BLOOD PLASMA PROTEIN GIVEN BY VEIN UTILIZED IN BODY METABOLISM : II. A DYNAMIC EQUILIBRIUM BETWEEN PLASMA AND TISSUE PROTEINS



Russell L. Holman M.D.1, Earle B. Mahoney 1, and George H. Whipple M.D.1

1 From the Department of Pathology, School of Medicine and Dentistry, The University of Rochester, Rochester, N. Y.

Large amounts of normal blood plasma can be given intravenously to normal dogs over several weeks without causing any significant escape by way of the urine. There appears to be no renal threshold for plasma protein even with high plasma protein concentration (9.7 per cent).

Dogs receiving sugar by mouth and plasma by vein can be kept practically in nitrogen equilibrium and it would seem that the injected protein must be utilized by the body. If this can happen in this emergency we may suspect that normally there is a certain amount of "give and take" between body protein and plasma protein.

Plasma protein fed by mouth under identical conditions shows the same general reaction as noted with plasma by vein but the urinary nitrogen is a little higher and suggests that the injected protein is utilized a little more completely to form new protein. The difference may be explained as due to deaminization in the case of protein by mouth.

During fasting periods the blood plasma proteins are used up and the total circulating protein may even decrease to one-half the normal level. The plasma protein concentration changes but little and the significant change is a shrinkage of plasma volume.

All these facts point to a dynamic equilibrium between tissue protein and plasma protein depending upon the physiological needs of the moment. In the absence of food protein the body can use material coming from one body protein to fabricate badly needed protein material of different character.

 Submitted on December 8, 1933


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