SEROLOGICAL REACTIONS IN PNEUMONIA WITH A NON-PROTEIN SOMATIC FRACTION OF PNEUMOCOCCUS

doi:10.1084/jem.52.4.561

This Article

	Full Text (PDF, 533K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Tillett, W. S.
	Articles by Francis, T.
	Search for Related Content

PubMed

	Articles by Tillett, W. S.
	Articles by Francis, T., Jr.

Social Bookmarking

	What's this?

The Journal of Experimental Medicine, Vol 52, 561-571, Copyright, 1930, by The Rockefeller Institute for Medical Research New York

ARTICLE

SEROLOGICAL REACTIONS IN PNEUMONIA WITH A NON-PROTEIN SOMATIC FRACTION OF PNEUMOCOCCUS

William S. Tillett M.D.¹ and Thomas Francis Jr. M.D.¹

¹ From the Hospital of The Rockefeller Institute for Medical Research

1. Sera from individuals acutely ill with lobar pneumonia possessthe capacity to precipitate in high titre a non-protein somaticfraction derived from pneumococci (Fraction C). Following crisisthe reaction is no longer demonstrable.

2. Sera obtained fromcases of pneumococcus pneumonia during illness and convalescencehave been tested for antibodies specifically reactive with threechemically distinct constituents of Pneumococcus. The results,when correlated with the course of disease, demonstrate differencesin the occurrence of each qualitatively distinct antibody.

3.The precipitation of pneumococcus Fraction C is not limitedto the sera of individuals ill with pneumococcus infection.But in the few other cases available for comparative tests,definite reactions have been obtained only in streptococcusand staphylococcus infections and in acute rheumatic fever.

Submitted on June 25, 1930

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Sierros, V, Fleming, R, Cascioli, M, Brady, T (2009). The prognostic value of C-reactive protein in long-term care patients requiring prolonged mechanical ventilation. Chronic Respiratory Disease 6: 149-155 [Abstract]
Almeida, O. P, Norman, P. E, Allcock, R., Bockxmeer, F. v., Hankey, G. J, Jamrozik, K., Flicker, L. (2009). Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: The Health in Men Study. Int J Epidemiol 38: 1049-1059 [Abstract] [Full Text]
Ridker, P. M (2009). C-Reactive Protein: Eighty Years from Discovery to Emergence as a Major Risk Marker for Cardiovascular Disease. Clin. Chem. 55: 209-215 [Full Text]
Montecucco, F., Mach, F. (2009). Common inflammatory mediators orchestrate pathophysiological processes in rheumatoid arthritis and atherosclerosis. Rheumatology (Oxford) 48: 11-22 [Abstract] [Full Text]
Pedersen, B. K., Febbraio, M. A. (2008). Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6. Physiol. Rev. 88: 1379-1406 [Abstract] [Full Text]
Casey, R., Newcombe, J., McFadden, J., Bodman-Smith, K. B. (2008). The Acute-Phase Reactant C-Reactive Protein Binds to Phosphorylcholine-Expressing Neisseria meningitidis and Increases Uptake by Human Phagocytes. Infect. Immun. 76: 1298-1304 [Abstract] [Full Text]
Mizgerd, J. P. (2008). Acute Lower Respiratory Tract Infection. NEJM 358: 716-727 [Full Text]
Judge, M. S. (2008). Infection and Neuroarthropathy: The Utility of C-reactive Protein as a Screening Tool in the Charcot Foot. J. Am. Podiatr. Med. Assoc. 98: 1-6 [Abstract] [Full Text]
Hage, F. G., Szalai, A. J. (2007). C-Reactive Protein Gene Polymorphisms, C-Reactive Protein Blood Levels, and Cardiovascular Disease Risk. J Am Coll Cardiol 50: 1115-1122 [Abstract] [Full Text]
Kalantar-Zadeh, K. (2007). Inflammatory Marker Mania in Chronic Kidney Disease: Pentraxins at the Crossroad of Universal Soldiers of Inflammation. CJASN 2: 872-875 [Full Text]
Thomas-Rudolph, D., Du Clos, T. W., Snapper, C. M., Mold, C. (2007). C-Reactive Protein Enhances Immunity to Streptococcus pneumoniae by Targeting Uptake to Fc{gamma}R on Dendritic Cells. J. Immunol. 178: 7283-7291 [Abstract] [Full Text]
Revkin, J. H., Shear, C. L., Pouleur, H. G., Ryder, S. W., Orloff, D. G. (2007). Biomarkers in the Prevention and Treatment of Atherosclerosis: Need, Validation, and Future. Pharmacol. Rev. 59: 40-53 [Abstract] [Full Text]
Capuzzi, D. M., Freeman, J. S. (2007). C-Reactive Protein and Cardiovascular Risk in the Metabolic Syndrome and Type 2 Diabetes: Controversy and Challenge. Clin. Diabetes 25: 16-22 [Abstract] [Full Text]
Schett, G., Kiechl, S., Weger, S., Pederiva, A., Mayr, A., Petrangeli, M., Oberhollenzer, F., Lorenzini, R., Redlich, K., Axmann, R., Zwerina, J., Willeit, J. (2006). High-Sensitivity C-Reactive Protein and Risk of Nontraumatic Fractures in the Bruneck Study. Arch Intern Med 166: 2495-2501 [Abstract] [Full Text]
Howard-Alpe, G. M., Sear, J. W., Foex, P. (2006). Methods of detecting atherosclerosis in non-cardiac surgical patients; the role of biochemical markers. Br J Anaesth 97: 758-769 [Abstract] [Full Text]
Messer, J. V. (2006). C-Reactive Protein and Cardiovascular Disease. Circulation 114: e253-e254 [Full Text]
Albert, M. A., Ridker, P. M (2006). C-Reactive Protein as a Risk Predictor: Do Race/Ethnicity and Gender Make a Difference?. Circulation 114: e67-e74 [Full Text]
Paffen, E., deMaat, M. P.M. (2006). C-reactive protein in atherosclerosis: A causal factor?. Cardiovasc Res 71: 30-39 [Abstract] [Full Text]
Mold, C., Du Clos, T. W. (2006). C-Reactive Protein Increases Cytokine Responses to Streptococcus pneumoniae through Interactions with Fc{gamma} Receptors.. J. Immunol. 176: 7598-7604 [Abstract] [Full Text]
Guven, A., Cetinkaya, A., Aral, M., Sokmen, G., Buyukbese, M. A., Guven, A., Koksal, N. (2006). High-Sensitivity C-Reactive Protein in Patients with Metabolic Syndrome. ANGIOLOGY 57: 295-302 [Abstract]
O'BRIEN, S. M., SCOTT, L. V., DINAN, T. G. (2006). Antidepressant therapy and C-reactive protein levels. Br. J. Psychiatry 188: 449-452 [Abstract] [Full Text]
Vermeire, S, Van Assche, G, Rutgeerts, P (2006). Laboratory markers in IBD: useful, magic, or unnecessary toys?. Gut 55: 426-431 [Full Text]
Biasucci, L M, Giubilato, G, Graziani, F, Piro, M (2005). CRP is or is not a reliable marker of ischaemic heart disease?. Lupus 14: 752-755 [Abstract]
Huntley, J S, Kelly, M B (2005). C-reactive protein: a valuable acute investigation. A case of pneumococcal meningitis presenting as ankle pain. Emerg. Med. J. 22: 602-603 [Abstract] [Full Text]
Black, S., Wilson, A., Samols, D. (2005). An Intact Phosphocholine Binding Site Is Necessary for Transgenic Rabbit C-Reactive Protein to Protect Mice against Challenge with Platelet-Activating Factor. J. Immunol. 175: 1192-1196 [Abstract] [Full Text]
Black, S., Kushner, I., Samols, D. (2004). C-reactive Protein. J. Biol. Chem. 279: 48487-48490 [Abstract] [Full Text]
Fransson, B. A., Karlstam, E., Bergstrom, A., Lagerstedt, A.-S., Park, J. S., Evans, M. A., Ragle, C. A. (2004). C-reactive Protein in the Differentiation of Pyometra From Cystic Endometrial Hyperplasia/Mucometra in Dogs. Journal of the American Animal Hospital Association 40: 391-399 [Abstract] [Full Text]
Ng, P. M.L., Zhenxiao Jin, , Tan, S. S.H., Ho, B., Ding, J. L. (2004). C-reactive protein: a predominant LPS-binding acute phase protein responsive to Pseudomonas infection. Innate Immunity 10: 163-174 [Abstract]
Luna, C. M. (2004). C-Reactive Protein in Pneumonia: Let Me Try Again. Chest 125: 1192-1195 [Full Text]
Pasche, B., Serhan, C. N. (2004). Is C-Reactive Protein an Inflammation Opsonin That Signals Colon Cancer Risk?. JAMA 291: 623-624 [Full Text]
Hirschfield, G.M., Pepys, M.B. (2003). C-reactive protein and cardiovascular disease: new insights from an old molecule. QJM 96: 793-807 [Abstract] [Full Text]
Ledue, T. B., Rifai, N. (2003). Preanalytic and Analytic Sources of Variations in C-reactive Protein Measurement: Implications for Cardiovascular Disease Risk Assessment. Clin. Chem. 49: 1258-1271 [Abstract] [Full Text]
Aziz, N., Fahey, J. L., Detels, R., Butch, A. W. (2003). Analytical Performance of a Highly Sensitive C-Reactive Protein-Based Immunoassay and the Effects of Laboratory Variables on Levels of Protein in Blood. CVI 10: 652-657 [Abstract] [Full Text]
Futterman, L. G., Lemberg, L. (2003). A Quick Test Predicts Acute Coronary Events. Am J Crit Care 12: 262-266 [Full Text]
McCowan, T. C., Eidt, J. F. (2003). Angioplasty, C-reactive Protein, and the Patient at Risk. Radiology 227: 314-315 [Full Text]
Ford, E. S., Giles, W. H., Myers, G. L., Mannino, D. M. (2003). Population Distribution of High-Sensitivity C-reactive Protein among US Men: Findings from National Health and Nutrition Examination Survey 1999-2000. Clin. Chem. 49: 686-690 [Full Text]
Zimmerman, M. A., Selzman, C. H., Cothren, C., Sorensen, A. C., Raeburn, C. D., Harken, A. H. (2003). Diagnostic Implications of C-Reactive Protein. Arch Surg 138: 220-224 [Abstract] [Full Text]
Yeh, E. T.H., Willerson, J. T. (2003). Coming of Age of C-Reactive Protein: Using Inflammation Markers in Cardiology. Circulation 107: 370-371 [Full Text]
Toh, C. H., Samis, J., Downey, C., Walker, J., Becker, L., Brufatto, N., Tejidor, L., Jones, G., Houdijk, W., Giles, A., Koschinsky, M., Ticknor, L. O., Paton, R., Wenstone, R., Nesheim, M. (2002). Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca++-dependent complex of C-reactive protein with very-low-density lipoprotein and is a novel marker of impending disseminated intravascular coagulation. Blood 100: 2522-2529 [Abstract] [Full Text]
Agrawal, A., Simpson, M. J., Black, S., Carey, M. P., Samols, D. (2002). A C-Reactive Protein Mutant That Does Not Bind to Phosphocholine and Pneumococcal C-Polysaccharide. J. Immunol. 169: 3217-3222 [Abstract] [Full Text]
Szalai, A. J., Nataf, S., Hu, X.-Z., Barnum, S. R. (2002). Experimental Allergic Encephalomyelitis Is Inhibited in Transgenic Mice Expressing Human C-Reactive Protein. J. Immunol. 168: 5792-5797 [Abstract] [Full Text]
Levinson, S. S., Elin, R. J. (2002). What Is C-Reactive Protein Telling Us About Coronary Artery Disease?. Arch Intern Med 162: 389-392 [Full Text]
Hegele, R. A., Ban, M. R., Young, T. K. (2001). Serum C-Reactive Protein in Canadian Inuit and Its Association with Genetic Variation on Chromosome 1q21. Clin. Chem. 47: 1707-1709 [Full Text]
Yeh, E. T.H., Anderson, H. V., Pasceri, V., Willerson, J. T. (2001). C-Reactive Protein: Linking Inflammation to Cardiovascular Complications. Circulation 104: 974-975 [Full Text]
Agrawal, A., Shrive, A. K., Greenhough, T. J., Volanakis, J. E. (2001). Topology and Structure of the C1q-Binding Site on C-Reactive Protein. J. Immunol. 166: 3998-4004 [Abstract] [Full Text]
Gershov, D., Kim, S., Brot, N., Elkon, K. B. (2000). C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response: Implications for Systemic Autoimmunity. JEM 192: 1353-1364 [Abstract] [Full Text]
Culley, F. J., Bodman-Smith, K. B., Ferguson, M. A. J., Nikolaev, A. V., Shantilal, N., Raynes, J. G. (2000). C-reactive protein binds to phosphorylated carbohydrates. Glycobiology 10: 59-65 [Abstract] [Full Text]
Gabay, C., Kushner, I. (1999). Acute-Phase Proteins and Other Systemic Responses to Inflammation. NEJM 340: 448-454 [Full Text]
Wilkins, J., Gallimore, J. R., Moore, E. G., Pepys, M. B. (1998). Rapid Automated High Sensitivity Enzyme Immunoassay of C-Reactive Protein. Clin. Chem. 44: 1358-1361 [Full Text]
Gambino, R. (1997). C-Reactive Protein�Undervalued, Underutilized. Clin. Chem. 43: 2017-2018 [Full Text]
Lagrand, W. K., Niessen, H. W.M., Wolbink, G.-J., Jaspars, L. H., Visser, C. A., Verheugt, F. W.A., Meijer, C. J.L.M., Hack, C. E. (1997). C-Reactive Protein Colocalizes With Complement in Human Hearts During Acute Myocardial Infarction. Circulation 95: 97-103 [Abstract] [Full Text]
Dyck, R. F., Bingham, W., Tan, L., Rogers, S. L. (1984). Serum Levels of C-reactive Protein in Neonatal Respiratory Distress Syndrome. CLIN PEDIATR 23: 381-383 [Abstract]
Schentag, J. J., O'Keeffe, D., Marmion, M., Wels, P. B. (1984). C-Reactive Protein as an Indicator of Infection Relapse in Patients With Abdominal Sepsis. Arch Surg 119: 300-304 [Abstract]
Whitehead, A., Bruns, G., Markham, A., Colten, H., Woods, D. (1983). Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1. Science 221: 69-71 [Abstract]
McCarthy, P. L., Tomasso, L., Dolan, T. F. JR (1980). Predicting Fever Response of Children with Pneumonia Treated with Antibiotics. CLIN PEDIATR 19: 753-760 [Abstract]
Croft, S., Mortensen, R., Gewurz, H (1976). Binding of C-reactive protein to antigen-induced but not mitogen-induced T lymphoblasts. Science 193: 685-687 [Abstract]
FREMONT, R. E., LOSNER, S., VOLK, B. W. (1958). The Fibrinogen Polymerization Test in Nonspecific Myocarditis and Pericarditis. Arch Intern Med 102: 41-49 [Abstract]
WOOD, H. F., DIAMOND, H. D., CRAVER, L. F., PADER, E., ELSTER, S. K. (1958). DETERMINATION OF C-REACTIVE PROTEIN IN THE BLOOD OF PATIENTS WITH HODGKIN'S DISEASE. ANN INTERN MED 48: 823-833 [Abstract]
PAGE, A. R., GOOD, R. A. (1957). Studies on Cyclic Neutropenia: A Clinical and Experimental Investigation. Arch Pediatr Adolesc Med 94: 623-661 [Abstract]
YOCUM, R. S., DOERNER, A. A. (1957). A Clinical Evaluation of the C-Reactive Protein Test. Arch Intern Med 99: 74-81 [Abstract]
KOZONIS, M. C., GUREVIN, I. (1957). THE VALUE OF THE C-REACTIVE PROTEIN DETERMINATION IN CORONARY ARTERY DISEASE. ANN INTERN MED 46: 79-85 [Abstract]
Knights, E. M. Jr., Hutchins, M., Morgan, E., Ploompuu, J. (1956). USE OF THE C-REACTIVE PROTEIN TEST AS A SCREENING PROCEDURE FOR BLOOD DONORS. JAMA 162: 9-13 [Abstract]
ROANTREE, R. J., RANTZ, L. A. (1955). Clinical experience with the C-Reactive Protein Test. Arch Intern Med 96: 674-682 [Abstract]
Sprunt, D. H., Hale, W. M., Chang, F. C., Richmond, S. G., Erickson, C. C. (1955). Present Status Cancer Tests. Science 122: 273-274
ROTHBARD, S., WATSON, R. F., SWIFT, H. F., WILSON, A. T. (1948). BACTERIOLOGIC AND IMMUNOLOGIC STUDIES ON PATIENTS WITH HEMOLYTIC STREPTOCOCCIC INFECTIONS AS RELATED TO RHEUMATIC FEVER. Arch Intern Med 82: 229-250 [Abstract]
HARKAVY, J., HEBALD, S. (1932). ASSOCIATION OF INFECTIOUS ASTHMA AND ARTHRITIS FROM THE POINT OF VIEW OF BACTERIAL ALLERGY. Arch Intern Med 49: 698-708 [Abstract]