The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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The Journal of Experimental Medicine, Vol 52, 533-538, Copyright, 1930, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON A-AVITAMINOSIS IN CHICKENS : II. LESIONS OF THE UPPER ALIMENTARY TRACT AND THEIR RELATION TO SOME INFECTIOUS DISEASES



Oskar Seifried V.M.D.1

1 From the Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.

When fowls are placed on a diet lacking in vitamin A lesions appear in the upper alimentary tract which are confined largely to the mucous glands and their ducts. Histologically it is shown that the original epithelium becomes replaced by a stratified squamous keratinizing epithelium and that secondary infections are relatively common. The ducts of the glands may be blocked leading to distention with secretions and necrotic materials. These lesions macroscopically resemble very closely certain stages of fowl-pox and the two conditions can be separated only by histological examination. It is pointed out that these lesions produced by a lack of vitamin A may enable bacteria and other viruses to enter the body.

Submitted on June 18, 1930


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