The Journal of Experimental Medicine
Torrey Pines Biolabs
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 718K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ecker, E. E.
Right arrow Articles by Welch, H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Ecker, E. E.
Right arrow Articles by Welch, H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
The Journal of Experimental Medicine, Vol 51, 409-423, Copyright, 1930, by The Rockefeller Institute for Medical Research New York

ARTICLE

CUTANEOUS REACTIONS WITH CULTURE FILTRATES OF THE COLON TYPHOID TYPE

E. E. Ecker Ph.D.1 and H. Welch 1

1 From the Institute of Pathology and the Department of Hygiene and Bacteriology, Western Reserve University, Cleveland

The observations of Ecker and Rimington on the production of skin reactions with synthetic medium culture filtrates (concentrated and dialyzed) of organisms belonging to the colon-typhoid group have been confirmed and extended.

The filtrates show a marked degree of thermostability and marked resistance to ultraviolet radiation.

Intravenous injections of the filtrates stimulate the production of precipitins. No precipitins are produced in the sera of rabbits that receive intracutaneous injections only.

At no time during the course of immunization was the skin reaction obliterated. An indurative process was noted at the site of injection (skin) during the course of immunization. Mixtures of the filtrates with their homologous antisera, obtained from animals immunized by the intravenous route, and injected into skin, also failed to obliterate the erythema and edema.

The observations of Shwartzman have been confirmed; the Shwartzman phenomenon appears to be group or species specific. Filtrates from enterococci failed to produce the phenomenon. Filtrates of other unrelated organisms have not been studied.

The products of Shwartzman and of Ecker and Rimington appear to be the same.

 Submitted on November 19, 1929


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS