The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 51, 5-14, Copyright, 1930, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY : VI. THE EFFECT OF ENDOTHELIAL BLOCKADE ON THE STORAGE AND DISTRIBUTION OF NEOARSPHENAMINE



Claus W. Jungeblut M.D.1 and Barbara R. McGinn 1

1 From the Department of Bacteriology and Experimental Pathology, Stanford University, California

1. Blockade of the reticulo-endothelial system by means of a single injection of India ink caused a marked retention of neoarsphenamine in the blood of guinea pigs during the first twenty minutes of observation after intravenous injection, as contrasted with the rapid disappearance of the drug from the blood of normal controls.

2. Rabbits blocked by a single dose of India ink showed a slower elimination of the drug from the circulation following the first few hours after intravenous injection than corresponding controls.

3. The arsenic content of the liver of mice, which received neoarsphenamine intravenously after a preceding blocking injection with India ink, was appreciably lower than the arsenic content of the normal organ under similar experimental conditions.

 Submitted on September 3, 1929


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