The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 51, 27-39, Copyright, 1930, by The Rockefeller Institute for Medical Research New York

ARTICLE

IS THE LOCAL VASODILATATION AFTER DIFFERENT TISSUE INJURIES REFERABLE TO A SINGLE CAUSE?

Peyton Rous M.D.1 and H. P. Gilding B.M., B.Ch.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

Experiment shows that the vascular contraction responsible for Bier's spotting prevails over the local vasodilatation due to mechanical injury of the skin, and causes the local reddening to blanch. It is without effect, however, upon the local vasodilatation caused by histamine pricked into the skin. The results raise doubts concerning the validity of the hypothesis referring all local vasodilatations to the action of a single chemical substance or set of substances ("H substance"), liberated within the tissues.

Submitted on October 22, 1929


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