The Journal of Experimental Medicine, Vol 50, 793-801,
Copyright, 1929, by The Rockefeller Institute for Medical Research New York
STUDIES ON YELLOW FEVER IN SOUTH AMERICA
:
IV. TRANSMISSION EXPERIMENTS WITH AËDES AEGYPTI
Nelson C. Davis M.D.1 and
Raymond C. Shannon 1
1 From the Yellow Fever Laboratory of the International Health Division of the Rockefeller Foundation, Bahia, Brazil
1. Batches of Aëdes (Stegomyia) aegypti which had fed on monkeys in the early febrile stage of yellow fever and which has subsequently passed the usually accepted extrinsic incubation period for the virus, failed to transmit the disease to normal monkeys in approximately fifty per cent of the experiments. During the same time over eighty per cent of blood transfers were successful.
2. The monkeys which failed to show fever following mosquito bites later proved resistant to the inoculation of blood or tissues containing virus.
3. The incubation, or afebrile, period in monkeys following the bites of infected mosquitoes varied from less than twenty-four hours to fifteen days. It averaged somewhat longer in non-fatal than in fatal infections.
Submitted on September 2, 1929
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