The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 50, 579-581, Copyright, 1929, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON IMMUNOLOGICAL RELATIONSHIPS AMONG THE PNEUMOCOCCI : IV. ACTIVE IMMUNIZATION OF MICE AGAINST TYPE II PNEUMOCOCCI BY VACCINATION WITH YEAST



John Y. Sugg 1, Lurline V. Richardson 1, and James M. Neill Ph.D.1

1 From the Department of Bacteriology and Immunology, Vanderbilt University Medical School, Nashville, Tennessee

Mice vaccinated with yeast were protected against subsequent infection with Type II pneumococci, but not against Types I or III. While the protection was not universal, as high a percentage of mice acquired active anti-Type II immunity, as was obtained by vaccination of another group of mice with Type II pneumococci themselves. This specific protection of mice by active immunization with the yeast antigen, is probably due to the same immunological relationship responsible for the anti-Type II reactivity of the antisera of rabbits immunized with yeast antigen.

Submitted on July 14, 1929


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