The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 50, 569-578, Copyright, 1929, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE LIVER AS THE SOURCE OF FIBRINOGEN

D. R. Drury M.D.1 and Philip D. McMaster M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

In hepatectomized rabbits a progressive decrease in blood fibrinogen occurs. Partial defibrination in the liverless rabbit invariably results in a progressive decrease in blood fibrinogen preceded by a temporary and slight rise. No evidence has been secured of fibrinogen regeneration in the absence of the liver. From this it follows that the liver is the essential source of fibrinogen and in all probability the sole one.

Submitted on June 20, 1929


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