The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 48, 805-809, Copyright, 1928, by The Rockefeller Institute for Medical Research New York

ARTICLE

SUPPRESSION OF THE FIRST ATTACK WITH SUBSEQUENT RELAPSE: AN IMMUNE PHENOMENON IN EXPERIMENTAL RELAPSING FEVER

Henry Edmund Meleney M.D.1

1 From the Department of Medicine, Peking Union Medical College, Peking, China, and the Department of Preventive Medicine and Public Health, Vanderbilt University, Nashville, Tennessee.

In five splenectomized squirrels and chipmunks which were reinoculated with a strain of Spironema recurrentis which had previously been present in their blood, the first attack was entirely suppressed because the animals were immune to the strain of spirochetes inoculated; but after the interval which usually occurred between attacks, a relapse ensued, in which the strain of spirochetes present in the blood was different from the strain inoculated.

Submitted on August 5, 1928


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