The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 46, 65-80, Copyright, 1927, by The Rockefeller Institute for Medical Research New York

ARTICLE

EFFECT OF HOST IMMUNITY TO A FILTERABLE VIRUS (VIRUS III) ON THE GROWTH AND MALIGNANCY OF A TRANSPLANTABLE RABBIT NEOPLASM

Louise Pearce M.D.1 and Thomas M. Rivers M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research.

Experiments are reported in which were studied the course and character of a transplantable malignant neoplasm in normal rabbits and in rabbits immunized with a filterable virus, Virus III.

The disease which developed in immunized rabbits was extremely mild and much less severe than in normal animals.

The effect upon the tumor process displayed by Virus III immune rabbits in the direction of diminished malignancy is considered to be entirely non-specific in character, and the suggestion is made that it is accomplished through a more effective resistance of the host.

 Submitted on March 21, 1927


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