The Journal of Experimental Medicine
Avanti Polar Lipids, Inc.
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 580K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, D. E.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Smith, D. E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
The Journal of Experimental Medicine, Vol 46, 155-166, Copyright, 1927, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES : IV. A BIOCHEMICAL STUDY OF THE CAPSULAR SUBSTANCE.



Dorothea E. Smith Ph.D.1

1 From the Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.

1. The soluble specific substance obtained from a capsulated strain of B. coli is not identical with any specific substance heretofore described. It is a carbohydrate, composed of 80 per cent of hexose, probably partly of dextro- and partly of levorotatory sugar, since the rotation of the hydrolysate is low. Glucuronic acid is probably present in the molecule.

2. Crude "residue" or specific substance obtained from the uncapsulated mutant was about 100 times less active with homologous serum than similar material from the capsulated strain. This supports the view that capsular substance and soluble specific substance are the same. In cases where there is a well marked capsule, the specific substance is probably produced in greater amount and located peripherally.

3. Capsular substance is probably significant for virulence when functioning as a morphological capsule. It is present in filtrates of young culture only in very small amounts.

 Submitted on March 17, 1927


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS