The Journal of Experimental Medicine
Torrey Pines Biolabs
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 484K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Neill, J. M.
Right arrow Articles by Gaspari, E. L.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Neill, J. M.
Right arrow Articles by Gaspari, E. L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
The Journal of Experimental Medicine, Vol 46, 113-122, Copyright, 1927, by The Rockefeller Institute for Medical Research New York

ARTICLE

FACTORS INVOLVED IN THE INFECTION OF MICE AFTER VACCINATION WITH TYPE II PNEUMOCOCCI

James M. Neill Ph.D.1 and Emidio L. Gaspari 1

1 From the Department of Bacteriology and Immunology, Vanderbilt University Medical School, Nashville.

A group of mice was vaccinated against Type II pneumoccci and subsequently tested for immunity against different numbers of the live bacteria. The immunity tests were conducted within two zones of dosage. In the first zone where the doses were kept within reasonable limits (10–6 to 10–3 cc. of culture), the number of invading bacteria was without influence and the occurrence of infections was determined by the previous immunity response of the individual. In the second zone of dosage (where passive protection also fails), these relations were reversed, and invasion by overwhelming numbers of the bacteria invariably produced infection regardless of the previous immunity response of the individual.

These results present an extreme example of the importance of the immunity response of the individual as a factor always concerned in the effectiveness of vaccination.

 Submitted on March 27, 1927


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS