The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 42, 821-828, Copyright, 1925, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE BACTERIOPHAGE OF D'HERELLE : IV. CONCERNING THE ONENESS OF THE BACTERIOPHAGE.



Jacques J. Bronfenbrenner Ph.D.1 and Charles Korb M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research.

Lytic filtrates, active against Bacillus dysenterioelig Shiga, Bacillus coli, Bacillus pestis cavioelig, and staphylococcus respectively, proved to be differently affected by changes in hydrogen ion concentration.

Anti-staphylococcus lysin was the least resistant of the four, showing deterioration in 3 hours at 7°C. beyond the zone of hydrogen ion concentration limited by CH = 6.3 x 10–5 and CH = 1.6 x 10–9. Under the same conditions, the zone of resistance of anti-coli filtrate lay between CH = 2.7 x 10–3 and CH = 2.5 x 10–11, and that of anti-Shiga between CH = 1-7 x 10–4 and CH = 1-3 x 10–11. Anti-pestis cavioelig filtrate was most resistant of the four, retaining its full activity in the zone from CH = 1 x 10–3 to CH = 3.5 x 10–12.

The fact that these differences in individual resistance persisted, notwithstanding the repeated passage of lytic filtrates through cultures of bacteria other than those against which they were primarily active, seems to offer evidence in favor of a multiplicity of bacteriophages.

 Submitted on August 3, 1925


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