The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 41, 631-638, Copyright, 1925, by The Rockefeller Institute for Medical Research New York

ARTICLE

PATHOLOGY OF THE EXPERIMENTAL PNEUMONIAS IN MICE FOLLOWING INHALATION OF STREPTOCOCCUS HÆMOLYTICUS, OF FRIEDLÄNDER'S BACILLUS, AND OF PNEUMOCOCCUS

Arnold Branch M.D.1 and Ernest G. Stillman M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research.

1. Pulmonary consolidation may be produced in normal mice by the inhalation of Friedländer's bacillus or Streptococcus hæmolylicus.

2. The initial lesion is in both instances interstitial in character and the spread is by way of the interstitial tissue, though the ultimate consolidation may come to resemble in the gross a lobar pneumonia.

3. The lesions grossly and microscopically may be distinguished from the lobar consolidation associated with pneumococcus infection of the lung.

4. Friedländer's bacillus and Streptococcus hæmolyticus give rise to pneumonia in mice previously normal, whereas the pneumococcus produces pulmonary lesions only under special circumstances, as when the animals are alcoholized after partial immunization.

 Submitted on February 16, 1925


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