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¹ Department of Parasitology, Leiden University Medical Centre, Leiden 2333 ZA, Netherlands
² Trudeau Institute, Saranac Lake, NY 12983
³ Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
⁴ School of Biology, University of Nottingham, Nottingham NG7 2RD, England, UK
⁵ Research Center Borstel, Borstel 23845, Germany

CORRESPONDENCE Gabriele Schramm: gschramm{at}fz-borstel.de OR Markus Mohrs: mmohrs{at}trudeauinstitute.org

Soluble egg antigens of the parasitic helminth Schistosoma mansoni (S. mansoni egg antigen [SEA]) induce strong Th2 responses both in vitro and in vivo. However, the specific molecules that prime the development of Th2 responses have not been identified. We report that omega-1, a glycoprotein which is secreted from S. mansoni eggs and present in SEA, is capable of conditioning human monocyte-derived dendritic cells in vitro to drive T helper 2 (Th2) polarization with similar characteristics as whole SEA. Furthermore, using IL-4 dual reporter mice, we show that both natural and recombinant omega-1 alone are sufficient to generate Th2 responses in vivo, even in the absence of IL-4R signaling. Finally, omega-1–depleted SEA displays an impaired capacity for Th2 priming in vitro, but not in vivo, suggesting the existence of additional factors within SEA that can compensate for the omega-1–mediated effects. Collectively, we identify omega-1, a single component of SEA, as a potent inducer of Th2 responses.

© 2009 Everts et al.
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