The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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Published online
doi:10.1084/jem.20091442
The Journal of Experimental Medicine, Vol. 206, No. 8, 1643-1646
The Rockefeller University Press, 0022-1007 $30.00
© Locksley
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COMMENTARY

 Nine lives: plasticity among T helper cell subsets

Richard M. Locksley

R.M. Locksley is at Department of Medicine, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143

CORRESPONDENCE R.M.L.: locksley{at}medicine.ucsf.edu


ABSTRACT
The division of labor among two types of T helper (Th) subsets, first described over 20 yr ago, has been buffeted by the discovery of new subsets and new cytokines that can be coaxed out of T cells with increasing disregard for the subset of origin. Although Th17 cells and regulatory T (T reg) cells are widely accepted subsets, and others are being proposed, their plasticity is difficult to reconcile with the definitions of Th subsets as put forth in the initial description of Th1 and Th2 cells. A deeper molecular context will be required to reconcile the ever-increasing complexity of effector T cells.

© 2009 Locksley
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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