The Journal of Experimental Medicine
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Published online
doi:10.1084/jem.20091094
The Journal of Experimental Medicine, Vol. 206, No. 6, 1215-1218
The Rockefeller University Press, 0022-1007 $30.00
© Brumme et al.
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COMMENTARY

 Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification

Zabrina L. Brumme and Bruce D. Walker

Z.L. Brumme and B.D. Walker are at the Ragon Institute of MGH, MIT and Harvard, Charlestown MA 02129; Z.L. Brumme is at the Faculty of Health Sciences, Simon Fraser University, Burnaby BC V5A 1S6, Canada

CORRESPONDENCE B.D.W.: bwalker{at}partners.org


ABSTRACT
Early control of HIV-1 infection is determined by a balance between the host immune response and the ability of the virus to escape this response. Studies using single-genome amplification now reveal new details about the kinetics and specificity of the CD8+ T cell response and the evolution of the virus during early HIV infection.

© 2009 Brumme and Walker
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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