The Journal of Experimental Medicine
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Published online
doi:10.1084/jem.20081385
The Journal of Experimental Medicine, Vol. 206, No. 3, 595-606
The Rockefeller University Press, 0022-1007 $30.00
© Auffray et al.
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ARTICLE

 CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

Cedric Auffray1, Darin K. Fogg1, Emilie Narni-Mancinelli2, Brigitte Senechal1, Celine Trouillet1,3, Noah Saederup4, Julia Leemput5, Karine Bigot5, Laura Campisi2, Marc Abitbol5, Thierry Molina1, Israel Charo4, David A. Hume6, Ana Cumano7, Gregoire Lauvau2, and Frederic Geissmann1,3

1 Laboratory of Biology of the Mononuclear Phagocyte System, Institut National de la Santé et de la Recherche Médicale (INSERM) U838, Université Paris-Descartes, 75015 Paris, France
2 INSERM U924, Université de Nice-Sophia Antipolis, 06560 Valbonne, France
3 Centre for inflammation Biology, Division of Immunity, Infection, and Inflammatory Diseases, King's College London, SE1 9RT London, England, UK
4 Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA 94158
5 Centre d'etude et de recherche therapeutique en ophtalmologie, Université Paris-Descartes, 75015 Paris, France
6 The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, EH25 9PS Roslin, Scotland, UK
7 INSERM U668, Unité de Développement des Lymphocytes, Institut Pasteur, 75015 Paris, France

CORRESPONDENCE Frederic Geissmann: frederic.geissmann{at}kcl.ac.uk

CX3CR1 expression is associated with the commitment of CSF-1R+ myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R+ CX3CR1+ macrophage/DC precursor (MDP) with other DC precursors and the role of CX3CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1+ inflammatory monocytes that differentiate into TipDCs during infection. CX3CR1 deficiency selectively impairs the recruitment of blood Gr1+ monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.

C. Auffray, D.K. Fogg, and E. Narni-Mancinelli contributed equally to this paper.

Abbreviations used: cDC, conventional DC; CDP, common DC precursor; GMP, granulocyte-macrophage progenitors; iNOS, inductible nitric oxide synthase; Lm, Listeria monocytogenes; MDP, macrophage/DC precursor; PDC, plasmacytoid DC; PI, propidium iodide; ROI, reactive oxygen intermediate.

© 2009 Auffray et al.
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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