The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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Published online
doi:10.1084/jem.20090093
The Journal of Experimental Medicine, Vol. 206, No. 2, 269-273
The Rockefeller University Press, 0022-1007 $30.00
© Pirofski et al.
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COMMENTARY

 Rethinking T cell immunity in oropharyngeal candidiasis

Liise-anne Pirofski and Arturo Casadevall

L.P. and A.C. are at the Departments of Medicine and Microbiology and Immunology of the Albert Einstein College of Medicine College of Medicine, Bronx, NY

CORRESPONDENCE A.C.: casadeva{at}aecom.yu.edu


ABSTRACT
The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. These findings clarify and extend our current thinking about how CD4 T cell deficiency influences susceptibility to OPC.

© 2009 Pirofski and Casadevall
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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