The Journal of Experimental Medicine
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Published online
doi:10.1084/jem.20091903
The Journal of Experimental Medicine, Vol. 206, No. 10, 2059-2066
The Rockefeller University Press, 0022-1007 $30.00
© Maizels et al.
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MEETING REVIEW

 Regulation of pathogenesis and immunity in helminth infections

Rick M. Maizels, Edward J. Pearce, David Artis, Maria Yazdanbakhsh, and Thomas A. Wynn

R.M.M. is at Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, Scotland, UK
E.J.P. is at Trudeau Institute, Saranac Lake, NY 12983
D.A. is at Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104
M.Y. is at Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
T.A.W. is at Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892

CORRESPONDENCE R.M.M.: rick.maizels{at}ed.ac.uk

Helminths are multicellular eukaryotic parasites that infect over one quarter of the world’s population. Through coevolution with the human immune system, these organisms have learned to exploit immunoregulatory pathways, resulting in asymptomatic tolerance of infections in many individuals. When infections and the resulting immune responses become dysregulated, however, acute and chronic pathologies often develop. A recent international meeting focused on how these parasites modulate host immunity and how control of parasitic and immunopathological disease might be achieved.

© 2009 Maizels et al.
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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