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¹ Experimental Pathology Unit, ² Center for Systems Biology, ³ Division of Gastroenterology, ⁴ Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114
⁵ Mucosal Immunology Laboratory, ⁶ MGH Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129
⁷ Harvard Medical School, Boston, MA 02116

CORRESPONDENCE Atsushi Mizoguchi: amizoguchi{at}partners.org

Over 80% of the body's activated B cells are located in mucosal sites, including the intestine. The intestine contains IgM⁺ B cells, but these cells have not been characterized phenotypically or in terms of their developmental origins. We describe a previously unidentified and unique subset of immunoglobulin M⁺ B cells that present with an AA4.1^–CD21^–CD23^– major histocompatibility complex class II^bright surface phenotype and are characterized by a low frequency of somatic hypermutation and the potential ability to produce interleukin-12p70. This B cell subset resides within the normal mucosa of the large intestine and expands in response to inflammation. Some of these intestinal B cells originate from the AA4.1⁺ immature B2 cell pool in the steady state and are also recruited from the recirculating naive B cell pool in the context of intestinal inflammation. They develop in an antigen-independent and BAFF-dependent manner in the absence of T cell help. Expansion of these cells can be induced in the absence of the spleen and gut-associated lymphoid tissues. These results describe the existence of an alternative pathway of B cell maturation in the periphery that gives rise to a tissue-specific B cell subset.

© 2008 Shimomura et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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